학술논문

Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy
Document Type
Review Paper
Source
Japanese Journal of Radiology: (formerly: Radiation Medicine). 42(8):801-819
Subject
Endometriosis
Deep endometriosis
Endometrioma
Malignant transformation
Magnetic resonance imaging (MRI)
Language
English
ISSN
1867-1071
1867-108X
Abstract
Endometriosis is a benign, common, but controversial disease due to its enigmatic etiopathogenesis and biological behavior. Recent studies suggest multiple genetic, and environmental factors may affect its onset and development. Genomic analysis revealed the presence of cancer-associated gene mutations, which may reflect the neoplastic aspect of endometriosis. The management has changed dramatically with the development of fertility-preserving, minimally invasive therapies. Diagnostic strategies based on these recent basic and clinical findings are reviewed. With a focus on the presentation of clinical cases, we discuss the imaging manifestations of endometriomas, deep endometriosis, less common site and rare site endometriosis, various complications, endometriosis-associated tumor-like lesions, and malignant transformation, with pathophysiologic conditions.