학술논문
Mitigation of SARS-CoV-2 transmission at a large public university
Document Type
Original Paper
Author
Ranoa, Diana Rose E.; Holland, Robin L.; Alnaji, Fadi G.; Green, Kelsie J.; Wang, Leyi; Fredrickson, Richard L.; Wang, Tong; Wong, George N.; Uelmen, Johnny; Maslov, Sergei; Weiner, Zachary J.; Tkachenko, Alexei V.; Zhang, Hantao; Liu, Zhiru; Ibrahim, Ahmed; Patel, Sanjay J.; Paul, John M.; Vance, Nickolas P.; Gulick, Joseph G.; Satheesan, Sandeep Puthanveetil; Galvan, Isaac J.; Miller, Andrew; Grohens, Joseph; Nelson, Todd J.; Stevens, Mary P.; Hennessy, P Mark; Parker, Jr, Robert C.; Santos, Edward; Brackett, Charles; Steinman, Julie D.; Fenner, Jr, Melvin R.; Dohrer, Kirstin; DeLorenzo, Michael; Wilhelm-Barr, Laura; Brauer, Brian R.; Best-Popescu, Catherine; Durack, Gary; Wetter, Nathan; Kranz, David M.; Breitbarth, Jessica; Simpson, Charlie; Pryde, Julie A.; Kaler, Robin N.; Harris, Chris; Vance, Allison C.; Silotto, Jodi L.; Johnson, Mark; Valera, Enrique Andres; Anton, Patricia K.; Mwilambwe, Lowa; Bryan, Stephen P.; Stone, Deborah S.; Young, Danita B.; Ward, Wanda E.; Lantz, John; Vozenilek, John A.; Bashir, Rashid; Moore, Jeffrey S.; Garg, Mayank; Cooper, Julian C.; Snyder, Gillian; Lore, Michelle H.; Yocum, Dustin L.; Cohen, Neal J.; Novakofski, Jan E.; Loots, Melanie J.; Ballard, Randy L.; Band, Mark; Banks, Kayla M.; Barnes, Joseph D.; Bentea, Iuliana; Black, Jessica; Busch, Jeremy; Conte, Abigail; Conte, Madison; Curry, Michael; Eardley, Jennifer; Edwards, April; Eggett, Therese; Fleurimont, Judes; Foster, Delaney; Fouke, Bruce W.; Gallagher, Nicholas; Gastala, Nicole; Genung, Scott A.; Glueck, Declan; Gray, Brittani; Greta, Andrew; Healy, Robert M.; Hetrick, Ashley; Holterman, Arianna A.; Ismail, Nahed; Jasenof, Ian; Kelly, Patrick; Kielbasa, Aaron; Kiesel, Teresa; Kindle, Lorenzo M.; Lipking, Rhonda L.; Manabe, Yukari C.; Mayes, Jade ́; McGuffin, Reubin; McHenry, Kenton G.; Mirza, Agha; Moseley, Jada; Mostafa, Heba H.; Mumford, Melody; Munoz, Kathleen; Murray, Arika D.; Nolan, Moira; Parikh, Nil A.; Pekosz, Andrew; Pflugmacher, Janna; Phillips, Janise M.; Pitts, Collin; Potter, Mark C.; Quisenberry, James; Rear, Janelle; Robinson, Matthew L.; Rosillo, Edith; Rye, Leslie N.; Sherwood, MaryEllen; Simon, Anna; Singson, Jamie M.; Skadden, Carly; Skelton, Tina H.; Smith, Charlie; Stech, Mary; Thomas, Ryan; Tomaszewski, Matthew A.; Tyburski, Erika A.; Vanwingerden, Scott; Vlach, Evette; Watkins, Ronald S.; Watson, Karriem; White, Karen C.; Killeen, Timothy L.; Jones, Robert J.; Cangellaris, Andreas C.; Martinis, Susan A.; Vaid, Awais; Brooke, Christopher B.; Walsh, Joseph T.; Elbanna, Ahmed; Sullivan, William C.; Smith, Rebecca L.; Goldenfeld, Nigel; Fan, Timothy M.; Hergenrother, Paul J.; Burke, Martin D.
Source
Nature Communications. 13(1)
Subject
Language
English
ISSN
2041-1723
Abstract
In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal “SHIELD: Target, Test, and Tell” program, with other non-pharmaceutical interventions, was employed to keep classrooms and laboratories open. The program included epidemiological modeling and surveillance, fast/frequent testing using a novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction, called covidSHIELD, and digital tools for communication and compliance. In Fall 2020, we performed >1,000,000 covidSHIELD tests, positivity rates remained low, we had zero COVID-19-related hospitalizations or deaths amongst our university community, and mortality in the surrounding Champaign County was reduced more than 4-fold relative to expected. This case study shows that fast/frequent testing and other interventions mitigated transmission of SARS-CoV-2 at a large public university.
Safely opening university campuses has been a major challenge during the COVID-19 pandemic. Here, the authors describe a program of public health measures employed at a university in the United States which, combined with other non-pharmaceutical interventions, allowed the university to stay open in fall 2020 with limited evidence of transmission.
Safely opening university campuses has been a major challenge during the COVID-19 pandemic. Here, the authors describe a program of public health measures employed at a university in the United States which, combined with other non-pharmaceutical interventions, allowed the university to stay open in fall 2020 with limited evidence of transmission.