학술논문
Immunomodulation and Humoral Immune Response in Teleost Immunized with Aeromonas-Derived Antigenic Extracellular Bioactive Molecules
Document Type
Original Paper
Author
Fatsi, Patrick Senam Kofi; Kawai, Koichiro; Asmah, Ruby; Oppong, Betty Bandoh; Appiah, Ebenezer Koranteng; Hashem, Shaharior; Addo, Acheampong; Kusorgbor, Joyce Kplorla; Magna, Emmanuel Kaboja; Obeng, Abraham Kusi; Quansah, Lydia; Saba, Courage Kosi Setsoafia; Bawah, Juliana; Setufe, Seyramsarah Blossom; Adu-Nti, Frank; Ameworwor, Miriam Yayra; Quansah, Clara Ruth; Saito, Hidetoshi; Johnson-Ashun, Mercy; Osei, Lilly Konadu; Agbeko, Etornyo; Anani, Francis Assogba; Agyakwah, Seth Koranteng
Source
Indian Journal of Microbiology. 64(3):1110-1122
Subject
Language
English
ISSN
0046-8991
0973-7715
0973-7715
Abstract
The common use of antimicrobials in food-animal production can lead to drug residues in edible tissues for consumers. However, immunomodulators enhance immune responses and vaccine effectiveness. A new perspective explores bacterial extracellular bioactive molecules (EBMs) in food-animal production to modulate host immune responses, potentially transforming pathogen management and antimicrobial use. This study investigates the immunogenic potential of Aeromonas hydrophila-derived EBMs (Antigens) to enhance the immune system. Four Antigens were administered intraperitoneally to Oreochromis niloticus (Nile Tilapia). Antigens 2 and Antigens 3 boosted fish immune competence within 21 days. Remarkably, Antigens 3 induced robust immunity against A. hydrophila with a single dose, notably enhancing antibody-based immune responses. The increased antibody activity suggests Antigens 3 could be a vaccine candidate, promising further research and potential application in food-animal production to improve disease control. This study highlights immunomodulators' potential in reshaping disease management in the food-animal industry, emphasizing the benefits of focusing on bacterial EBMs to reduce reliance on antimicrobials and achieve sustainable disease prevention.