학술논문
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)
Document Type
Original Paper
Author
García de Guadiana-Romualdo, Luis; Rodríguez Rojas, Carlos; Morell-García, Daniel; Andaluz-Ojeda, David; Rodríguez Mulero, María Dolores; Rodríguez-Borja, Enrique; Ballesteros-Vizoso, Antonieta; Calvo, María Dolores; Albert-Botella, Lourdes; Pozo Giráldez, Adela; Llompart-Alabern, Isabel; Bolado Jiménez, Cristina; Hernández Olivo, Marta; Fernández Presa, Lucía; Ortega-Pérez, Juan; Fora Romero, María José; Campos-Rodríguez, Valerio; Ballester Férriz, Andrea; Guiu-Martí, Alexandra M.; Pinilla Arribas, Leyre; Galindo Martínez, María; Puerto-Lara, Edwin R.; López Tarazaga, Ana Belen; Ros Braquehais, María Salomé; Nogales Martín, Leonor; Juez Santamaría, Celia; Trapiello Fernández, Wysalli; Espinilla Fernández, Virginia; Havelka, Aleksandra; Albaladejo-Otón, María Dolores
Source
Inflammation Research: Official Journal of:The International Association of Inflammation Societies +The European Histamine Research Society. 71(1):57-67
Subject
Language
English
ISSN
1023-3830
1420-908X
1420-908X
Abstract
Objective: Severe COVID-19 is characterized by a dysregulated immune response in which neutrophils play a critical role. Calprotectin reflects neutrophil activation and is involved in the self-amplifying thrombo-inflammatory storm in severe COVID-19. We aimed to evaluate the role of calprotectin in early prediction of severity in COVID-19 patients.Methods: This was a multicenter prospective observational study enrolling consecutive adult COVID-19 patients. On arrival to emergency department, blood samples were collected for laboratory tests, including serum calprotectin. The primary outcome was severe respiratory failure requiring invasive mechanical ventilation and the secondary outcome was need for Intensive Care Unit (ICU) admission.Results: Study population included 395 patients, 57 (14.4%) required invasive mechanical ventilation and 100 (25.3%) were admitted to ICU. Median serum calprotectin levels were significantly higher in intubated (3.73 mg/L vs. 2.63 mg/L; p < 0.001) and ICU patients (3.48 mg/L vs. 2.60 mg/L; p = 0.001). Calprotectin showed a significant accuracy to predict the need for invasive mechanical ventilation (ROC AUC 0.723) and ICU admission (ROC AUC 0.650). In multivariate analysis, serum calprotectin was an independent predictor of invasive mechanical ventilation (OR 1.161) and ICU admission (OR 1.068).Conclusion: Serum calprotectin can be used as an early predictor of severity in COVID-19 patients.