학술논문
Solid-State Stability Issues of Drugs in Transdermal Patch Formulations
Document Type
Review Paper
Author
Source
AAPS PharmSciTech: An Official Journal of the American Association of Pharmaceutical Scientists. :1-9
Subject
Language
English
ISSN
1530-9932
Abstract
The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery. However, the instability of solid-state drugs is one of the most critical problems observed in transdermal patch products. Therefore, a well-characterized approach for counteracting stability problems in solid-state drugs is crucial for improving the performance of transdermal patch products. This review provides insight into the solid-state stability of drugs associated with transdermal patch products and offers a comprehensive update on the various approaches being used for improving the stability of the active pharmaceutical ingredients currently being used.