학술논문
ortho-Quinone drugs go pro
Document Type
Brief Communication
Author
Source
Nature Chemistry. 14(7):719-720
Subject
Language
English
ISSN
1755-4330
1755-4349
1755-4349
Abstract
Antibody-mediated delivery of therapeutics has been primarily limited to agents containing amine, alcohol or thiol functional groups. Now, an approach has been developed to create stable and bio-reversible prodrugs that mask ortho-quinones. Drug release requires both protease activation followed by acid-assisted elimination.