학술논문
ATX restricts anti-tumor eosinophil responses
Document Type
Brief Communication
Author
Source
Nature Cancer. 5(2):221-223
Subject
Language
English
ISSN
2662-1347
Abstract
Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.