학술논문

Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography
Document Type
Original Paper
Source
Bulletin of Experimental Biology and Medicine. August 2016 161(4):616-621
Subject
3D polymeric scaffolds
two-photon polymerization
calcium imaging
microstereolithography
dissociated hippocampal cultures
Language
English
ISSN
0007-4888
1573-8221
Abstract
We developed and tested new 3D scaffolds for neurotransplantation. Scaffolds of predetermined architectonic were prepared using microstereolithography technique. Scaffolds were highly biocompatible with the nervous tissue cells. In vitro studies showed that the material of fabricated scaffolds is not toxic for dissociated brain cells and promotes the formation of functional neural networks in the matrix. These results demonstrate the possibility of fabrication of tissue-engineering constructs for neurotransplantation based on created scaffolds.