학술논문
Antileishmanial Activity and Chemical Composition of Hydroalcoholic Extracts from Different Parts of Handroanthus impetiginosus (Ipê-Roxo)
Document Type
Brief Communication
Author
Mariano, Roberta Lopes; Montagnini, Daniel Luiz; Manuquian, Hallana Alves; Katchborian-Neto, Albert; dos Santos Ribeiro Cavallari, Pedro Sandoval; de Almeida, Samarah Gomes; Januário, Ana Helena; Pauletti, Patricia Mendonça; Magalhães, Lizandra Guide; da Silva, Camila de Paula Ferreira; Campos, Othon Souto; Cunha, Wilson Roberto; Santos, Mario Ferreira Conceição; Silva, Márcio Luís Andrade e
Source
Revista Brasileira de Farmacognosia: Brazilian Journal of Pharmacognosy. 32(5):851-857
Subject
Language
English
ISSN
1981-528X
Abstract
Abstract: Leishmaniasis is a parasitic disease with a limited arsenal of drugs for therapeutical care, and the available treatments present a variety of side effects, demonstrating the need for alternative therapies. Handroanthus impetiginosus (Mart. ex DC.) Mattos, Bignoniaceae (ipê-roxo), is recognized for showing a wide number of biological activities. Hence, this paper aims to investigate the extracts of different parts of H. impetiginosus and their antileishmanial activity through in vitro assays. The evaluation of the antileishmanial activity of the leaf and seed ethanolic extracts showed the best results after 24 h with IC50 4.49 and 2.24 µg/ml, respectively. Already, amphotericin B (positive control) showed an IC50 of 0.012 µg/ml. The chemical composition revealed metabolites such as flavonoids, triterpenoids, iridoid glycosides, hydroxyanthraquinones, naphtofurans, naphthoquinones, coumaric acid derivatives, lignans, and phenolic compounds. The results obtained in this paper contribute to the scientific knowledge regarding the chemical profile and biological potential of ipê-roxo.Graphical abstract: