학술논문
The silence of the reactive astrocytes
Document Type
Brief Communication
Author
Source
Nature Neuroscience. 27(4):607-609
Subject
Language
English
ISSN
1097-6256
1546-1726
1546-1726
Abstract
Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et al. develop a screening platform to unbiasedly identify modulators of astrocyte reactivity. They discover that HDAC3 inhibitors regulate astrocyte transitions into their reactive phenotype in vitro and in vivo.