학술논문
PS15 - 76. The Toll like receptor 3 in adipose tissue determines local inflammation
Document Type
Report
Author
Source
Nederlands Tijdschrift voor Diabetologie. November 2011 9(3):142-143
Subject
Language
English
ISSN
1567-2743
1876-6242
1876-6242
Abstract
Obesity is associated with inflammation at the level of the fat tissue, but the initiating mechanisms are unclear. Toll like receptors (TLRs) are at the frontline of innate immunity. TLRs sense specific exogenous and endogenous ligands. TLR3 typically recognizes double-stranded RNA. Although expression of TLR3 in adipocytes has been shown, the functional effects of TLR3 stimulation in adipocytes are unknown.