부산대학교 도서관

Background: Several countries with long-standing salt iodization programs, including Switzerland, have recently reported declining and/or low urinary iodine (UI) levels in their populations. In Switzerland, in response to studies indicating low UI levels in children and pregnant women, the salt iodine level was increased in 1998 from 15 to 20 mg/kg.Objective: Our objective was to evaluate iodine nutrition in a national sample of Swiss school children and pregnant women 8–16 months after the increase in the salt iodine level.Design: A 3-stage probability proportionate to size cluster sampling method was used to obtain a representative national sample of 600 children aged 6–12 y and 600 pregnant women. We then measured UI in both groups, thyrotropin (TSH) in pregnant women and thyroid volume by ultrasound to determine goiter prevalence in school children.Results: The median UI (range) of the children and pregnant women was 115 μg/l (5–413) and 138 μg/l (5–1881), respectively. The median blood TSH concentration (range) of pregnant women was 0.6 mU/l (0.2–2.1). Based on the current WHO/ICCIDD normative data for thyroid volume, none of the children were goitrous, using either age/sex-specific or BSA/sex-specific cutoffs.Conclusions: The iodine status of the Swiss population is once again adequate, illustrating the value of periodic monitoring and prudent adjustments to the iodine level in salt. This approach could serve as a model for countries struggling to maintain dietary iodine intake in the face of shifting dietary habits and changes in the food supply.Sponsorship: Swiss Foundation for Nutrition Research, Zürich, Switzerland; Foundation for Micronutrients in Medicine, Rapperswil, Switzerland; and Swiss Federal Institute of Technology in Zürich, Switzerland.European Journal of Clinical Nutrition (2001) 55, 162–166