학술논문
An international multidisciplinary consensus statement on MAFLD and the risk of CVD
Document Type
Original Paper
Author
Zhou, Xiao-Dong; Targher, Giovanni; Byrne, Christopher D.; Somers, Virend; Kim, Seung Up; Chahal, C. Anwar A.; Wong, Vincent Wai-Sun; Cai, Jingjing; Shapiro, Michael D.; Eslam, Mohammed; Steg, Philippe Gabriel; Sung, Ki-Chul; Misra, Anoop; Li, Jian-Jun; Brotons, Carlos; Huang, Yuli; Papatheodoridis, George V.; Sun, Aijun; Yilmaz, Yusuf; Chan, Wah Kheong; Huang, Hui; Méndez-Sánchez, Nahum; Alqahtani, Saleh A.; Cortez-Pinto, Helena; Lip, Gregory Y. H.; de Knegt, Robert J.; Ocama, Ponsiano; Romero-Gomez, Manuel; Fudim, Marat; Sebastiani, Giada; Son, Jang Won; Ryan, John D.; Ikonomidis, Ignatios; Treeprasertsuk, Sombat; Pastori, Daniele; Lupsor-Platon, Monica; Tilg, Herbert; Ghazinyan, Hasmik; Boursier, Jerome; Hamaguchi, Masahide; Nguyen, Mindie H.; Fan, Jian-Gao; Goh, George Boon-Bee; Al Mahtab, Mamun; Hamid, Saeed; Perera, Nilanka; George, Jacob; Zheng, Ming-Hua
Source
Hepatology International. 17(4):773-791
Subject
Language
English
ISSN
1936-0533
1936-0541
1936-0541
Abstract
Background: Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25–30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined with obesity, type 2 diabetes mellitus and atherogenic dyslipidemia, which are established cardiovascular risk factors. Unlike CVD, which has received attention in the literature on fatty liver disease, the CVD risk associated with MAFLD is often underestimated, especially among Cardiologists.Methods and results: A multidisciplinary panel of fifty-two international experts comprising Hepatologists, Endocrinologists, Diabetologists, Cardiologists and Family Physicians from six continents (Asia, Europe, North America, South America, Africa and Oceania) participated in a formal Delphi survey and developed consensus statements on the association between MAFLD and the risk of CVD. Statements were developed on different aspects of CVD risk, ranging from epidemiology to mechanisms, screening, and management.Conculsions: The expert panel identified important clinical associations between MAFLD and the risk of CVD that could serve to increase awareness of the adverse metabolic and cardiovascular outcomes of MAFLD. Finally, the expert panel also suggests potential areas for future research.