학술논문
Reduced Phenytoin Levels in an Epileptic Patient following Roux-En-Y Gastric Bypass for Obesity
Document Type
Report
Source
Obesity Surgery: The Journal of Metabolic Surgery and Allied Care. May 2011 21(5):684-685
Subject
Language
English
ISSN
0960-8923
1708-0428
1708-0428
Abstract
Despite widespread uptake of bariatric procedures for severe obesity, changes in pharmacodynamics after surgery are poorly understood. We report an epileptic patient who had a seizure following gastric bypass, although he had been asymptomatic for 30 years and without any change in his treatment. Phenytoin levels were undetectable despite a high dose. Drugs with a narrow therapeutic range such as phenytoin should be prescribed with caution after bariatric surgery.