학술논문
Modified carbon flux during oxygen limited growth of Corynebacterium glutamicum and the consequences for amino acid overproduction
Document Type
Original Paper
Author
Source
Biotechnology Letters. May 1993 15(5):449-454
Subject
Language
English
ISSN
0141-5492
1573-6776
1573-6776
Abstract
Summary:The amino acid producing bacterium Corynebacterium glutamicum accumulated lactate, succinate and acetate under oxygen-limited growth conditions. Significant restructuring of carbon flux through the central metabolic pathways occurred with a notable decrease in pentose pathway flux and the operation of the TCA cycle in a reductive mode. Simultaneous consumption of residual sugar and organic acids took place when oxygen sufficient conditions were restored though amino acids yields were significantly perturbed.