학술논문
Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment
Document Type
Original Paper
Author
Onkar, Sayali; Cui, Jian; Zou, Jian; Cardello, Carly; Cillo, Anthony R.; Uddin, Mostofa Rafid; Sagan, April; Joy, Marion; Osmanbeyoglu, Hatice U.; Pogue-Geile, Katherine L.; McAuliffe, Priscilla F.; Lucas, Peter C.; Tseng, George C.; Lee, Adrian V.; Bruno, Tullia C.; Oesterreich, Steffi; Vignali, Dario A. A.
Source
Nature Cancer. 4(4):516-534
Subject
Language
English
ISSN
2662-1347
Abstract
T cell-centric immunotherapies have shown modest clinical benefit thus far for estrogen receptor-positive (ER+ ) breast cancer. Despite accounting for 70% of all breast cancers, relatively little is known about the immunobiology of ER+ breast cancer in women with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC). To investigate this, we performed phenotypic, transcriptional and functional analyses for a cohort of treatment-naive IDC (n = 94) and ILC (n = 87) tumors. We show that macrophages, and not T cells, are the predominant immune cells infiltrating the tumor bed and the most transcriptionally diverse cell subset between IDC and ILC. Analysis of cellular neighborhoods revealed an interplay between macrophages and T cells associated with longer disease-free survival in IDC but not ILC. Our datasets provide a rich resource for further interrogation into immune cell dynamics in ER+ IDC and ILC and highlight macrophages as a potential target for ER+ breast cancer.
Using single-cell and high-dimensional profiling of the immune microenvironment, Vignali and colleagues uncover distinct cell subsets and interactions in human invasive ductal and lobular breast carcinoma, with potential prognostic and therapeutic relevance.
Using single-cell and high-dimensional profiling of the immune microenvironment, Vignali and colleagues uncover distinct cell subsets and interactions in human invasive ductal and lobular breast carcinoma, with potential prognostic and therapeutic relevance.