부산대학교 도서관

The prevalence of obesity has greatly increased over the past 30 years in men of reproductive age, concomitantly with an increase in infertility currently affecting one in six couples in France. In this context, several studies have been carried out on the potential implication of adipokines, adipose tissue secretion products, on reproductive functions. Although many studies have focused on female fertility, few have looked at the male side. We review here the human studies published on the relationships between adipokines of the seminal plasma and male fertility. Thus, if seminal adiponectin appears to have a positive effect on sperm parameters, other adipokines such as resistin or chemerin would have a rather deleterious effect on spermatogenesis. A dual role of leptin appears to be evolving with a physiological effect at lower concentrations and a deleterious effect at higher seminal concentrations.