부산대학교 도서관

Abstract: Blood transfusions are frequently used in cardiac surgeries. The purpose of this study is to determine the blood and its related products transfusion in patients undergoing cardio-pulmonary bypass (CPB), as well as to determine the complications of blood transfusions and their effects on the clinical outcome of the patients. A total of 2182 patients aged 18 years or older who underwent coronary artery bypass graft (CABG), valvular surgery, or combined CABG and valvular surgery were included. All red blood cell (RBCs), fresh frozen plasma (FFP), and platelet (PLT) transfusion in operation room, pre-pump, during pump, post-pump, and in intensive care unit (ICU) were recorded. RBCs were transfused in 1423 patients, FFP in 580 patients, platelet in 373 patients, and fibrinogen in 37 patients during 1 year. The volume of bleeding was significantly higher in patients with RBCs transfusion compared to patients who did not transfuse RBCs (p < 0.05). There were a higher incidence of reoperation (p: 0.01), cardiovascular (p: 0.01), and renal complication (p: 0.001) in patients with RBCs transfusion. The multivariate analysis showed that age (OR: 0.60, CI 95%: 0.33–0.97, p: 0.02), activated clotting time (ACT) of pre pump (OR: 0.80, CI 95%: 0.70–0.94, p: 0.004), and duration of pump time (OR: 0.70, CI 95%: 0.56–0.88, p: 0.002) are strong predictor of RBCs transfusion in patients who underwent cardiac surgery. Our findings showed that patients who underwent cardiac surgery in our center receive a relatively higher number of blood or blood component during and after an operation. Age, ACT of pre pump, and duration of pump time were strong predictors of RBCs transfusion.