학술논문
Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
Document Type
report
Author
Source
Journal of the Brazilian Chemical Society. July 2017 28(7)
Subject
Language
English
ISSN
0103-5053
Abstract
Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.