학술논문
Enzyme linked immunosorbent assay: determination of anti-adenovirus antibodies in an infant population
Document Type
article
Author
Source
Revista do Instituto de Medicina Tropical de São Paulo. October 1989 31(5)
Subject
Language
English
ISSN
0036-4665
Abstract
In order to define an accurate assay for anti-adenovirus antibody detection, a recently developed ELISA was compared with IFA and CF. On 58 sera, the ELISA was more sensitive than both CF and IFA, which showed relative sensitivities of 63% and 94%, respectively. It was not possible to determine the exact specificity of the tests because of the lack of a gold standard. Furthermore, the ELISA was used to define the prevalence of adenovirus antibodies in 116 infants between 1 and 24 months old (mean 7.28). The data showed that maternal antibodies waned by the age of 5 to 6 months and that more than 80% of the children had been infected by adenoviruses by the age of 10 months.