학술논문
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
Document Type
other
Author
Source
Memórias do Instituto Oswaldo Cruz. May 2009 104(3)
Subject
Language
English
ISSN
0074-0276
Abstract
An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.