학술논문
What are the barriers to participation in a neuromodulation pilot trial for aphasia after stroke?
Document Type
other
Author
Andreoli, Mariana Lopes; Souza, Juli Thomaz de; Ribeiro, Priscila Watson; Costa, Rafael Dalle Molle da; Silva, Taís Regina da; Winckler, Fernanda Cristina; Modolo, Gabriel Pinheiro; Alves, Karen Fernanda; Hamamoto Filho, Pedro Tadao; Garcia, Rafael Delascio; Betting, Luiz Eduardo Gomes Garcia; Bazan, Silmeia Garcia Zanati; Bazan, Rodrigo; Luvizutto, Gustavo José
Source
CoDAS. January 2021 33(4)
Subject
Language
English
ISSN
2317-1782
Abstract
Purpose Aphasia is a common and debilitating manifestation of stroke. Transcranial electrical stimulation uses low-intensity electric currents to induce changes in neuronal activity. Recent evidence suggests that noninvasive techniques can be a valuable rehabilitation tool for patients with aphasia. However, it is difficult to recruit patients with aphasia for trials, and the reasons for this are not well understood. This study aimed to elucidate the main difficulties involved in patient’s recruitment and inclusion in a randomized clinical study of neuromodulation in aphasia. Methods We evaluated the reasons for the exclusion of patients in a pilot, randomized, double-blinded clinical trial in which patients diagnosed with motor aphasia after stroke were recruited from March to November 2018. A descriptive statistical analysis was performed. Results Only 12.9% (4) of patients with ischemic stroke were included in the clinical trial. A total of 87.1% (27) of the 31 recruited patients were excluded for various reasons including: sensory aphasia (32.2%), dysarthria (25.8%), spontaneous clinical recovery (16.1%), previous stroke (6.4%), and death or mutism (3.2%). Conclusion The presence of other types of aphasia, dysarthria, spontaneous recovery, deaths, and mutism were barriers to recruiting patients evidenced in this neuromodulation study.