학술논문
Extreme phenotypes approach to investigate host genetics and COVID-19 outcomes
Document Type
article
Author
Naslavsky, Michel Satya; Vidigal, Mateus; Matos, Larissa do Rêgo Barros; Cória, Vivian Romanholi; Batista Junior, Pedro Benedito; Razuk, Álvaro; Saldiva, Paulo Hilário Nascimento; Dolhnikoff, Marisa; Schidlowski, Laire; Prando, Carolina; Cunha-Neto, Edécio; Condino-Neto, Antonio; Passos-Bueno, Maria Rita; Zatz, Mayana
Source
Genetics and Molecular Biology. January 2021 44(1)
Subject
Language
English
ISSN
1415-4757
Abstract
COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential candidate genes and pathways. Finally, we propose a strategy of subject’s ascertainment based on phenotypic extremes to take part in genomic studies and elucidate intrinsic risk factors involved in COVID-19 severe outcomes.