학술논문
Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression
Document Type
article
Author
SEVIM, Serhan; DEMIRKIRAN, Meltem; TERZI, Murat; YÜCEYAR, Nur; TAŞDELEN, Bahar; İDIMAN, Egemen; KÜRTÜNCÜ, Murat; BOZ, Cavit; TUNCEL, Deniz; KARABUDAK, Rana; SIVA, Aksel; ÖZCAN, Abdülcemal; NEYAL, Münife; GÖKSEL, Başak Karakurum; GAZALOĞLU, Gülcan Baran; BALAL, Mehmet; ŞEN, Sedat; BAKLAN, Meltem Alkaya; GÜNDÜZ, Tuncay; TUNCER, Aslı; UYGUNOĞLU, Uğur
Source
Arquivos de Neuro-Psiquiatria. February 2022 80(2)
Subject
Language
English
ISSN
0004-282X
Abstract
Background: Among the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS. Objective: To investigate the psychiatric burden of MS and RLS coexistence, we conducted a nationwide, multicenter and cross-sectional survey. Methods: Participants were assessed by using demographic and clinical parameters along with the Hamilton Anxiety and Hamilton Depression Scales (HAM-A and HAM-D). Results: Out of the 1,068 participants, 173 (16.2%) were found to have RLS [RLS(+)] and 895 (83.8%) did not [RLS(-)]. The mean scores for HAM-A and HAM-D were significantly higher among RLS(+) subjects than among RLS(-) subjects (p<0.001 for all variables). Conclusions: According to our data, the presence of RLS in PwMS may increase the occurrence of both anxiety and depression symptoms. Awareness and treatment of RLS in PwMS could possibly reduce the symptoms of psychiatric comorbidities originating from RLS.