학술논문
In vitro evaluation of Clostridium septicum alpha toxoid
Document Type
article
Author
Source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. August 2010 62(4)
Subject
Language
English
ISSN
0102-0935
Abstract
Aiming to investigate in vitro alternatives, a test for neutralizing antibody detection using cell culture was developed. This test was more sensitive than previous animal models, allowing for detection of substantially lower alpha toxin and anti-alpha toxin titers. Titers observed during in vivo and in vitro seroneutralization had a correlation of 99.12%, indicating that cell culture is a viable alternative in the evaluation of vaccine potency, screening of vaccinal seeds, and Clostridium septicum alpha toxin titration.