학술논문
Antifungal activity of natural and synthetic amides from Piper species
Document Type
article
Author
Source
Journal of the Brazilian Chemical Society. January 2010 21(10)
Subject
Language
English
ISSN
0103-5053
Abstract
The antifungal leaves extract from Piper scutifolium was submitted to bioactivity-guided chromatographic separation against Cladosporium cladosporioides and C. sphaerospermum yielding piperine, piperlonguminine and corcovadine as the active principles which displayed a detection limit of 1 µg. Structure-activity relationships were investigated with the preparation of twelve analogs having differences in the number of unsaturations, aromatic ring substituents and in the amide moiety. Analogs having a single double-bond and no substituent in the aromatic ring displayed higher activity, while N,N,-diethyl analogs displayed higher dose-dependent activity.