학술논문
Enantioselective transport of R-clenbuterol through a bulk liquid membrane containing O,O'-dibenzoyl-(2S, 3S)-tartaric
Document Type
article
Author
Source
Journal of the Brazilian Chemical Society. January 2007 18(4)
Subject
Language
English
ISSN
0103-5053
Abstract
A method of bulk liquid membrane (BLM) using O, O'-dibenzoyl-(2S, 3S)-tartaric acid was developed for the enantioselective transport of racemic clenbuterol. The influence of buffer pH, concentration ratio of chiral carrier to clenbuterol were studied. It was an appropriate choice of such as pH 7 in aqueous solution and concentration ratio of 1:4. The model of kinetic transport was established by means of a kinetic model involving two consecutive irreversible first order reactions. The pseudo-first order apparent rate constants were determined. It is helpful for optimizing the transport of BLM systems and realizing the large-scale production of pure enantiomer.