학술논문
Desenvolvimento e caracterização de nanopartículas lipídicas destinadas à aplicação tópica de dapsona
Document Type
article
Author
Source
Química Nova. January 2012 35(7)
Subject
Language
Portuguese
ISSN
0100-4042
Abstract
In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).