학술논문
Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
Document Type
other
Source
Revista da Sociedade Brasileira de Medicina Tropical. January 2020 53
Subject
Language
English
ISSN
0037-8682
Abstract
INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. METHODS: In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced. RESULTS: All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene. CONCLUSIONS: This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.