학술논문
Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review
Document Type
article
Author
Conceição, Emilyn Costa; Salvato, Richard Steiner; Gomes, Karen Machado; Guimarães, Arthur Emil dos Santos; da Conceição, Marília Lima; Souza e Guimarães, Ricardo José de Paula; Sharma, Abhinav; Furlaneto, Ismari Perini; Barcellos, Regina Bones; Bollela, Valdes Roberto; Anselmo, Lívia Maria Pala; Sisco, Maria Carolina; Niero, Cristina Viana; Ferrazoli, Lucilaine; Refrégier, Guislaine; Lourenço, Maria Cristina da Silva; Gomes, Harrison Magdinier; de Brito, Artemir Coelho; Catanho, Marcos; Duarte, Rafael Silva; Suffys, Philip Noel; Lima, Karla Valéria Batista
Source
Memórias do Instituto Oswaldo Cruz. January 2021 116
Subject
Language
English
ISSN
0074-0276
Abstract
Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.