학술논문
COVID-19: The question of genetic diversity and therapeutic intervention approaches
Document Type
article
Author
Figueiredo, David Livingstone Alves; Ximenez, João Paulo Bianchi; Seiva, Fábio Rodrigues Ferreira; Panis, Carolina; Bezerra, Rafael dos Santos; Ferrasa, Adriano; Cecchini, Alessandra Lourenço; Medeiros, Alexandra Ivo de; Almeida, Ana Marisa Fusco; Ramão, Anelisa; Boldt, Angelica Beate Winter; Moya, Carla Fredrichsen; Chin, Chung Man; Paula, Daniel de; Rech, Daniel; Gradia, Daniela Fiori; Malheiros, Danielle; Venturini, Danielle; Tavares, Eliandro Reis; Carraro, Emerson; Ribeiro, Enilze Maria de Souza Fonseca; Pereira, Evani Marques; Tuon, Felipe Francisco; Follador, Franciele Aní Caovilla; Fernandes, Glaura Scantamburlo Alves; Volpato, Hélito; Cólus, Ilce Mara de Syllos; Oliveira, Jaqueline Carvalho de; Rodrigues, Jean Henrique da Silva; Santos, Jean Leandro dos; Visentainer, Jeane Eliete Laguila; Brandi, Juliana Cristina; Serpeloni, Juliana Mara; Bonini, Juliana Sartori; Oliveira, Karen Brajão de; Fiorentin, Karine; Lucio, Léia Carolina; Faccin-Galhardi, Ligia Carla; Ferreto, Lirane Elize Defante; Lioni, Lucy Megumi Yamauchi; Consolaro, Marcia Edilaine Lopes; Vicari, Marcelo Ricardo; Arbex, Marcos Abdo; Pileggi, Marcos; Watanabe, Maria Angelica Ehara; Costa, Maria Antônia Ramos; Giannini, Maria José S. Mendes; Amarante, Marla Karine; Khalil, Najeh Maissar; Lima Neto, Quirino Alves de; Herai, Roberto H.; Guembarovski, Roberta Losi; Shinsato, Rogério N.; Mainardes, Rubiana Mara; Giuliatti, Silvana; Yamada-Ogatta, Sueli Fumie; Gerber, Viviane Knuppel de Quadros; Pavanelli, Wander Rogério; Silva, Weber Claudio da; Petzl-Erler, Maria Luiza; Valente, Valeria; Soares, Christiane Pienna; Cavalli, Luciane Regina; Silva Jr, Wilson Araujo
Source
Genetics and Molecular Biology. January 2021 44(1)
Subject
Language
English
ISSN
1415-4757
Abstract
Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.