학술논문

The landscape of recombination in African Americans
Document Type
article
Author
Source
Nature. 476(7359)
Subject
Biological Sciences
Genetics
Biotechnology
Human Genome
Africa
Western
Black or African American
Alleles
Amino Acid Motifs
Base Sequence
Chromosome Mapping
Crossing Over
Genetic
Europe
Evolution
Molecular
Female
Gene Frequency
Genetics
Population
Genome
Human
Genomics
Haplotypes
Histone-Lysine N-Methyltransferase
Humans
Male
Molecular Sequence Data
Pedigree
Polymorphism
Single Nucleotide
Probability
White People
General Science & Technology
Language
Abstract
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P value