학술논문

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Document Type
article
Source
Neuro-Oncology. 22(8)
Subject
Neurosciences
Rare Diseases
Cancer
Brain Disorders
Brain Cancer
Good Health and Well Being
Brain Neoplasms
Chemoradiotherapy
Clinical Trials
Phase III as Topic
Consensus
Glioblastoma
Humans
Isocitrate Dehydrogenase
Randomized Controlled Trials as Topic
glioblastoma
diagnosis
therapy
clinical trials
Oncology and Carcinogenesis
Oncology & Carcinogenesis
Language
Abstract
Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.