학술논문
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Document Type
article
Author
Lango Allen, Hana; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I; Weedon, Michael N; Rivadeneira, Fernando; Willer, Cristen J; Jackson, Anne U; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R; Weyant, Robert J; Segrè, Ayellet V; Speliotes, Elizabeth K; Wheeler, Eleanor; Soranzo, Nicole; Park, Ju-Hyun; Yang, Jian; Gudbjartsson, Daniel; Heard-Costa, Nancy L; Randall, Joshua C; Qi, Lu; Vernon Smith, Albert; Mägi, Reedik; Pastinen, Tomi; Liang, Liming; Heid, Iris M; Luan, Jian’an; Thorleifsson, Gudmar; Winkler, Thomas W; Goddard, Michael E; Sin Lo, Ken; Palmer, Cameron; Workalemahu, Tsegaselassie; Aulchenko, Yurii S; Johansson, Åsa; Carola Zillikens, M; Feitosa, Mary F; Esko, Tõnu; Johnson, Toby; Ketkar, Shamika; Kraft, Peter; Mangino, Massimo; Prokopenko, Inga; Absher, Devin; Albrecht, Eva; Ernst, Florian; Glazer, Nicole L; Hayward, Caroline; Hottenga, Jouke-Jan; Jacobs, Kevin B; Knowles, Joshua W; Kutalik, Zoltán; Monda, Keri L; Polasek, Ozren; Preuss, Michael; Rayner, Nigel W; Robertson, Neil R; Steinthorsdottir, Valgerdur; Tyrer, Jonathan P; Voight, Benjamin F; Wiklund, Fredrik; Xu, Jianfeng; Hua Zhao, Jing; Nyholt, Dale R; Pellikka, Niina; Perola, Markus; Perry, John RB; Surakka, Ida; Tammesoo, Mari-Liis; Altmaier, Elizabeth L; Amin, Najaf; Aspelund, Thor; Bhangale, Tushar; Boucher, Gabrielle; Chasman, Daniel I; Chen, Constance; Coin, Lachlan; Cooper, Matthew N; Dixon, Anna L; Gibson, Quince; Grundberg, Elin; Hao, Ke; Juhani Junttila, M; Kaplan, Lee M; Kettunen, Johannes; König, Inke R; Kwan, Tony; Lawrence, Robert W; Levinson, Douglas F; Lorentzon, Mattias; McKnight, Barbara; Morris, Andrew P; Müller, Martina; Suh Ngwa, Julius; Purcell, Shaun; Rafelt, Suzanne; Salem, Rany M; Salvi, Erika
Source
Nature. 467(7317)
Subject
Language
Abstract
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P