학술논문
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
Document Type
article
Author
Küpers, Leanne K; Monnereau, Claire; Sharp, Gemma C; Yousefi, Paul; Salas, Lucas A; Ghantous, Akram; Page, Christian M; Reese, Sarah E; Wilcox, Allen J; Czamara, Darina; Starling, Anne P; Novoloaca, Alexei; Lent, Samantha; Roy, Ritu; Hoyo, Cathrine; Breton, Carrie V; Allard, Catherine; Just, Allan C; Bakulski, Kelly M; Holloway, John W; Everson, Todd M; Xu, Cheng-Jian; Huang, Rae-Chi; van der Plaat, Diana A; Wielscher, Matthias; Merid, Simon Kebede; Ullemar, Vilhelmina; Rezwan, Faisal I; Lahti, Jari; van Dongen, Jenny; Langie, Sabine AS; Richardson, Tom G; Magnus, Maria C; Nohr, Ellen A; Xu, Zongli; Duijts, Liesbeth; Zhao, Shanshan; Zhang, Weiming; Plusquin, Michelle; DeMeo, Dawn L; Solomon, Olivia; Heimovaara, Joosje H; Jima, Dereje D; Gao, Lu; Bustamante, Mariona; Perron, Patrice; Wright, Robert O; Hertz-Picciotto, Irva; Zhang, Hongmei; Karagas, Margaret R; Gehring, Ulrike; Marsit, Carmen J; Beilin, Lawrence J; Vonk, Judith M; Jarvelin, Marjo-Riitta; Bergström, Anna; Örtqvist, Anne K; Ewart, Susan; Villa, Pia M; Moore, Sophie E; Willemsen, Gonneke; Standaert, Arnout RL; Håberg, Siri E; Sørensen, Thorkild IA; Taylor, Jack A; Räikkönen, Katri; Yang, Ivana V; Kechris, Katerina; Nawrot, Tim S; Silver, Matt J; Gong, Yun Yun; Richiardi, Lorenzo; Kogevinas, Manolis; Litonjua, Augusto A; Eskenazi, Brenda; Huen, Karen; Mbarek, Hamdi; Maguire, Rachel L; Dwyer, Terence; Vrijheid, Martine; Bouchard, Luigi; Baccarelli, Andrea A; Croen, Lisa A; Karmaus, Wilfried; Anderson, Denise; de Vries, Maaike; Sebert, Sylvain; Kere, Juha; Karlsson, Robert; Arshad, Syed Hasan; Hämäläinen, Esa; Routledge, Michael N; Boomsma, Dorret I; Feinberg, Andrew P; Newschaffer, Craig J; Govarts, Eva; Moisse, Matthieu; Fallin, M Daniele; Melén, Erik; Prentice, Andrew M
Source
Nature communications. 10(1)
Subject
Language
Abstract
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni