학술논문
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Document Type
article
Author
Scott, Robert A; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-France; Shungin, Dmitry; Tönjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Nabila; Glazer, Nicole L; Jackson, Anne U; Kutalik, Zoltán; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik, Laura J; Stringham, Heather M; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lori L; Bornstein, Stefan R; Brunner, Eric; Bumpstead, Suzannah J; Brage, Soren; Carlson, Olga D; Chen, Han; Chen, Yii-Der Ida; Chines, Peter S; Collins, Francis S; Couper, David J; Dennison, Elaine M; Dowling, Nicole F; Egan, Josephine S; Ekelund, Ulf; Erdos, Michael R; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Grässler, Jürgen; Gustafsson, Stefan; Hallmans, Göran; Hansen, Torben; Hingorani, Aroon; Holloway, John W; Hu, Frank B; Isomaa, Bo; Jameson, Karen A; Johansson, Ingegerd; Jonsson, Anna; Jørgensen, Torben; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Laakso, Markku; Lecoeur, Cécile; Lévy-Marchal, Claire; Li, Guo; Loos, Ruth JF; Lyssenko, Valeri; Marmot, Michael; Marques-Vidal, Pedro; Morken, Mario A; Müller, Gabriele; North, Kari E; Pankow, James S; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M; Renström, Frida; Rice, Ken; Rotter, Jerome I; Rybin, Denis; Sandholt, Camilla H; Sayer, Avan A; Shrader, Peter; Schwarz, Peter EH; Siscovick, David S; Stančáková, Alena; Stumvoll, Michael; Teslovich, Tanya M; Waeber, Gérard; Williams, Gordon H; Witte, Daniel R; Wood, Andrew R; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philippe; Groop, Leif; Kao, WH Linda; Vollenweider, Peter; Walker, Mark; Watanabe, Richard M; Pedersen, Oluf; Meigs, James B
Source
Diabetes. 61(5)
Subject
Language
Abstract
Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.