학술논문
Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke
Document Type
article
Author
Yu, Di; Liang, Nuanyi; Zebarth, Julia; Shen, Qing; Ozzoude, Miracle; Goubran, Maged; Rabin, Jennifer S; Ramirez, Joel; Scott, Christopher JM; Gao, Fuqiang; Bartha, Robert; Symons, Sean; Haddad, Seyyed Mohammad Hassan; Berezuk, Courtney; Tan, Brian; Kwan, Donna; Hegele, Robert A; Dilliott, Allison A; Nanayakkara, Nuwan D; Binns, Malcolm A; Beaton, Derek; Arnott, Stephen R; Lawrence‐Dewar, Jane M; Hassan, Ayman; Dowlatshahi, Dar; Mandzia, Jennifer; Sahlas, Demetrios; Casaubon, Leanne; Saposnik, Gustavo; Otoki, Yurika; Lanctôt, Krista L; Masellis, Mario; Black, Sandra E; Swartz, Richard H; Taha, Ameer Y; Swardfager, Walter; Rashkovan, Natalie; Abrahao, Agessandro; Zinman, Lorne; Bonnick, Alisia; Scott, Christopher; Holmes, Melissa; Adamo, Sabrina; Freedman, Morris; Zamyadi, Mojdeh; Arnott, Stephen; Binns, Malcolm; Raamana, Pradeep; Strother, Stephen; Sunderland, Kelly; Theyers, Athena; Uthirakumaran, Abiramy; Levine, Brian; Troyer, Angela; Strong, Michael; Kleinstiver, Peter; Borrie, Michael; Finger, Elizabeth; Shoesmith, Christen; Faria, Frederico; Montero‐Odasso, Manuel; Sarquis‐Adamson, Yanina; Black, Alanna; Dilliott, Allison Ann; Hegele, Rob; Robinson, John; Farhan, Sali; Bartha, Rob; Haddad, Hassan; Nanayakkara, Nuwan; Zou, Guangyong; Pasternak, Stephen; Orange, JB; Roberts, Angela; Jog, Mandar; Seitz, Dallas; Brien, Don; Chen, Ying; Coe, Brian; Munoz, Doug; McLaughlin, Paula; Peltsch, Alicia; Bronskill, Susan; Lou, Wendy; Kumar, Sanjeev; Pollock, Bruce; Rajji, Tarek; Tang‐Wai, David; Tartaglia, Carmela
Source
Journal of the American Heart Association. 12(1)
Subject
Language
Abstract
Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic acid [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic acid [EpOME] and 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods and Results Participants with mild to moderate small vessel stroke or large vessel stroke were selected based on clinical and imaging criteria. Metabolites were quantified by ultra-high-performance liquid chromatography-mass spectrometry. Volumes of stroke, lacunes, white matter hyperintensities, magnetic resonance imaging visible perivascular spaces, and free water diffusion were quantified from structural and diffusion magnetic resonance imaging (3 Tesla). Adjusted linear regression models were used for analysis. Compared with participants with large vessel stroke (n=30), participants with small vessel stroke (n=50) had a higher 12,13-DiHOME/12(13)-EpOME ratio (β=0.251, P=0.023). The 12,13-DiHOME/12(13)-EpOME ratio was associated with more lacunes (β=0.266, P=0.028) but not with large vessel stroke volumes. Ratios of 12,13-DiHOME/12(13)-EpOME and 9,10-DiHOME/9(10)-EpOME were associated with greater volumes of white matter hyperintensities (β=0.364, P