학술논문
Remaining true to one’s identity
Document Type
article
Author
Source
Nature Aging. 1(9)
Subject
Language
Abstract
The ability to remain true to cellular identity and function is lost during aging and carcinogenesis when DNA damage triggers inflammation that progressively erodes homeostatic cues. Shalabi et al. show that these losses are accelerated in patients with germline cancer mutations in DNA repair genes and are independent of chronological age.