학술논문
Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19
Document Type
article
Author
Shah, Sachin J; Barish, Peter N; Prasad, Priya A; Kistler, Amy; Neff, Norma; Kamm, Jack; Li, Lucy M; Chiu, Charles Y; Babik, Jennifer M; Fang, Margaret C; Kangelaris, Kirsten Neudoerffer; Langelier, Charles; Group, the UCSF COVID-19 Hospital Translational and Clinical Epidemiology Working; Abe-Jones, Yumiko; Alipanah, Narges; Alvarez, Francisco N; Botvinnik, Olga Borisovna; Castaneda, Gloria; Consortium, The CZB CLIAhub; Dadasovich, Rand M; Davis, Jennifer; Deng, Xianding; DeRisi, Joseph L; Detweiler, Angela M; Federman, Scot; Haliburton, John; Hao, Samantha; Kerkhoff, Andrew D; Kumar, G Renuka; Malcolm, Katherine B; Mann, Sabrina A; Martinez, Sandra; Marya, Rupa K; Mick, Eran; Mwakibete, Lusajo; Najafi, Nader; Peluso, Michael J; Phelps, Maira; Pisco, Angela Oliveira; Ratnasiri, Kalani; Rubio, Luis A; Sellas, Anna; Sherwood, Kyla D; Sheu, Jonathan; Spottiswoode, Natasha; Tan, Michelle; Yu, Guixia
Source
medRxiv : the preprint server for health sciences. 1(06-05)
Subject
Language
Abstract
BACKGROUND:Emerging data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have largely been presented as case series. Few studies have compared these clinical features and outcomes of COVID-19 to other acute respiratory illnesses. METHODS:We examined all patients presenting to an emergency department in San Francisco, California between February 3 and March 31, 2020 with an acute respiratory illness who were tested for SARS-CoV-2. We determined COVID-19 status by PCR and metagenomic next generation sequencing (mNGS). We compared demographics, comorbidities, symptoms, vital signs, and laboratory results including viral diagnostics using PCR and mNGS. Among those hospitalized, we determined differences in treatment (antibiotics, antivirals, respiratory support) and outcomes (ICU admission, ICU interventions, acute respiratory distress syndrome, cardiac injury). FINDINGS:In a cohort of 316 patients, 33 (10%) tested positive for SARS-CoV-2; 31 patients, all without COVID-19, tested positive for another respiratory virus (16%). Among patients with additional viral testing, no co-infections with SARS-CoV-2 were identified by PCR or mNGS. Patients with COVID-19 reported longer symptoms duration (median 7 vs. 3 days), and were more likely to report fever (82% vs. 44%), fatigue (85% vs. 50%), and myalgias (61% vs 27%); p