학술논문
Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians
Document Type
article
Author
Chen, Peng; Takeuchi, Fumihiko; Lee, Jong-Young; Li, Huaixing; Wu, Jer-Yuarn; Liang, Jun; Long, Jirong; Tabara, Yasuharu; Goodarzi, Mark O; Pereira, Mark A; Kim, Young Jin; Go, Min Jin; Stram, Daniel O; Vithana, Eranga; Khor, Chiea-Chuen; Liu, Jianjun; Liao, Jiemin; Ye, Xingwang; Wang, Yiqin; Lu, Ling; Young, Terri L; Lee, Jeannette; Thai, Ah Chuan; Cheng, Ching-Yu; van Dam, Rob M; Friedlander, Yechiel; Heng, Chew-Kiat; Koh, Woon-Puay; Chen, Chien-Hsiun; Chang, Li-Ching; Pan, Wen-Harn; Qi, Qibin; Isono, Masato; Zheng, Wei; Cai, Qiuyin; Gao, Yutang; Yamamoto, Ken; Ohnaka, Keizo; Takayanagi, Ryoichi; Kita, Yoshikuni; Ueshima, Hirotsugu; Hsiung, Chao A; Cui, Jinrui; Sheu, Wayne H-H; Rotter, Jerome I; Chen, Yii-Der I; Hsu, Chris; Okada, Yukinori; Kubo, Michiaki; Takahashi, Atsushi; Tanaka, Toshihiro; van Rooij, Frank JA; Ganesh, Santhi K; Huang, Jinyan; Huang, Tao; Yuan, Jianmin; Hwang, Joo-Yeon; Group, CHARGE Hematology Working; Gross, Myron D; Assimes, Themistocles L; Miki, Tetsuro; Shu, Xiao-Ou; Qi, Lu; Chen, Yuan-Tson; Lin, Xu; Aung, Tin; Wong, Tien-Yin; Teo, Yik-Ying; Kim, Bong-Jo; Kato, Norihiro; Tai, E-Shyong
Source
Diabetes. 63(7)
Subject
Language
Abstract
Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (