학술논문
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
Document Type
article
Author
Amundadottir, Laufey; Kraft, Peter; Stolzenberg-Solomon, Rachael Z; Fuchs, Charles S; Petersen, Gloria M; Arslan, Alan A; Bueno-de-Mesquita, H Bas; Gross, Myron; Helzlsouer, Kathy; Jacobs, Eric J; LaCroix, Andrea; Zheng, Wei; Albanes, Demetrius; Bamlet, William; Berg, Christine D; Berrino, Franco; Bingham, Sheila; Buring, Julie E; Bracci, Paige M; Canzian, Federico; Clavel-Chapelon, Françoise; Clipp, Sandra; Cotterchio, Michelle; de Andrade, Mariza; Duell, Eric J; Fox, John W; Gallinger, Steven; Gaziano, J Michael; Giovannucci, Edward L; Goggins, Michael; González, Carlos A; Hallmans, Göran; Hankinson, Susan E; Hassan, Manal; Holly, Elizabeth A; Hunter, David J; Hutchinson, Amy; Jackson, Rebecca; Jacobs, Kevin B; Jenab, Mazda; Kaaks, Rudolf; Klein, Alison P; Kooperberg, Charles; Kurtz, Robert C; Li, Donghui; Lynch, Shannon M; Mandelson, Margaret; McWilliams, Robert R; Mendelsohn, Julie B; Michaud, Dominique S; Olson, Sara H; Overvad, Kim; Patel, Alpa V; Peeters, Petra HM; Rajkovic, Aleksandar; Riboli, Elio; Risch, Harvey A; Shu, Xiao-Ou; Thomas, Gilles; Tobias, Geoffrey S; Trichopoulos, Dimitrios; Van Den Eeden, Stephen K; Virtamo, Jarmo; Wactawski-Wende, Jean; Wolpin, Brian M; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquotte, Anne; Chanock, Stephen J; Hartge, Patricia; Hoover, Robert N
Source
Nature genetics. 41(9)
Subject
Language
Abstract
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.