학술논문
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
Document Type
article
Author
Haslam, Danielle E; Peloso, Gina M; Guirette, Melanie; Imamura, Fumiaki; Bartz, Traci M; Pitsillides, Achilleas N; Wang, Carol A; Li-Gao, Ruifang; Westra, Jason M; Pitkänen, Niina; Young, Kristin L; Graff, Mariaelisa; Wood, Alexis C; Braun, Kim VE; Luan, Jian'an; Kähönen, Mika; Kiefte-de Jong, Jessica C; Ghanbari, Mohsen; Tintle, Nathan; Lemaitre, Rozenn N; Mook-Kanamori, Dennis O; North, Kari; Helminen, Mika; Mossavar-Rahmani, Yasmin; Snetselaar, Linda; Martin, Lisa W; Viikari, Jorma S; Oddy, Wendy H; Pennell, Craig E; Rosendall, Frits R; Ikram, M Arfan; Uitterlinden, Andre G; Psaty, Bruce M; Mozaffarian, Dariush; Rotter, Jerome I; Taylor, Kent D; Lehtimäki, Terho; Raitakari, Olli T; Livingston, Kara A; Voortman, Trudy; Forouhi, Nita G; Wareham, Nick J; de Mutsert, Renée; Rich, Steven S; Manson, JoAnn E; Mora, Samia; Ridker, Paul M; Merino, Jordi; Meigs, James B; Dashti, Hassan S; Chasman, Daniel I; Lichtenstein, Alice H; Smith, Caren E; Dupuis, Josée; Herman, Mark A; McKeown, Nicola M
Source
Circulation. Genomic and precision medicine. 14(4)
Subject
Language
Abstract
BackgroundChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia.MethodsData from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake.ResultsIn a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; P