학술논문
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Document Type
article
Author
Suzuki, Ken; Hatzikotoulas, Konstantinos; Southam, Lorraine; Taylor, Henry; Yin, Xianyong; Lorenz, Kim; Mandla, Ravi; Huerta-Chagoya, Alicia; Melloni, Giorgio; Kanoni, Stavroula; Rayner, Nigel; Bocher, Ozvan; Arruda, Ana; Sonehara, Kyuto; Namba, Shinichi; Lee, Simon; Preuss, Michael; Petty, Lauren; Schroeder, Philip; Vanderwerff, Brett; Kals, Mart; Bragg, Fiona; Lin, Kuang; Guo, Xiuqing; Zhang, Weihua; Yao, Jie; Kim, Young; Graff, Mariaelisa; Takeuchi, Fumihiko; Nano, Jana; Lamri, Amel; Nakatochi, Masahiro; Moon, Sanghoon; Scott, Robert; Cook, James; Lee, Jung-Jin; Pan, Ian; Taliun, Daniel; Parra, Esteban; Chai, Jin-Fang; Bielak, Lawrence; Tabara, Yasuharu; Hai, Yang; Thorleifsson, Gudmar; Grarup, Niels; Sofer, Tamar; Wuttke, Matthias; Sarnowski, Chloé; Gieger, Christian; Nousome, Darryl; Trompet, Stella; Kwak, Soo-Heon; Long, Jirong; Sun, Meng; Tong, Lin; Chen, Wei-Min; Nongmaithem, Suraj; Noordam, Raymond; Lim, Victor; Tam, Claudia; Joo, Yoonjung; Chen, Chien-Hsiun; Raffield, Laura; Prins, Bram; Nicolas, Aude; Yanek, Lisa; Chen, Guanjie; Brody, Jennifer; Kabagambe, Edmond; An, Ping; Xiang, Anny; Choi, Hyeok; Cade, Brian; Tan, Jingyi; Broadaway, K; Williamson, Alice; Kamali, Zoha; Cui, Jinrui; Thangam, Manonanthini; Adair, Linda; Adeyemo, Adebowale; Aguilar-Salinas, Carlos; Ahluwalia, Tarunveer; Anand, Sonia; Bertoni, Alain; Bork-Jensen, Jette; Brandslund, Ivan; Buchanan, Thomas; Burant, Charles; Butterworth, Adam; Canouil, Mickaël; Chan, Juliana; Chang, Li-Ching; Chee, Miao-Li; Chen, Ji; Chen, Shyh-Huei; Chen, Yuan-Tsong; Chen, Zhengming; Chuang, Lee-Ming; Cushman, Mary
Source
Nature: New biology. 627(8003)
Subject
Language
Abstract
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P