학술논문
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
Document Type
article
Author
Zacarías-Fluck, Mariano F; Jauset, Toni; Martínez-Martín, Sandra; Kaur, Jastrinjan; Casacuberta-Serra, Sílvia; Massó-Vallés, Daniel; del Pozo, Erika Serrano; Martín-Fernández, Génesis; González-Larreategui, Íñigo; López-Estévez, Sergio; Brown-Swigart, Lamorna; Beaulieu, Marie-Eve; Whitfield, Jonathan R; Madan, Babita; Virshup, David M; Evan, Gerard I; Soucek, Laura
Source
Life Science Alliance. 4(5)
Subject
Language
Abstract
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.