학술논문
Apolipoprotein E epsilon 4 (APOE‐ε4) genotype is associated with decreased 6‐month verbal memory performance after mild traumatic brain injury
Document Type
article
Author
Yue, John K; Robinson, Caitlin K; Burke, John F; Winkler, Ethan A; Deng, Hansen; Cnossen, Maryse C; Lingsma, Hester F; Ferguson, Adam R; McAllister, Thomas W; Rosand, Jonathan; Burchard, Esteban G; Sorani, Marco D; Sharma, Sourabh; Nielson, Jessica L; Satris, Gabriela G; Talbott, Jason F; Tarapore, Phiroz E; Korley, Frederick K; Wang, Kevin KW; Yuh, Esther L; Mukherjee, Pratik; Diaz‐Arrastia, Ramon; Valadka, Alex B; Okonkwo, David O; Manley, Geoffrey T; Investigators, the TRACK‐TBI
Source
Brain and Behavior. 7(9)
Subject
Language
Abstract
IntroductionThe apolipoprotein E (APOE) ε4 allele associates with memory impairment in neurodegenerative diseases. Its association with memory after mild traumatic brain injury (mTBI) is unclear.MethodsmTBI patients (Glasgow Coma Scale score 13-15, no neurosurgical intervention, extracranial Abbreviated Injury Scale score ≤1) aged ≥18 years with APOE genotyping results were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study. Cohorts determined by APOE-ε4(+/-) were assessed for associations with 6-month verbal memory, measured by California Verbal Learning Test, Second Edition (CVLT-II) subscales: Immediate Recall Trials 1-5 (IRT), Short-Delay Free Recall (SDFR), Short-Delay Cued Recall (SDCR), Long-Delay Free Recall (LDFR), and Long-Delay Cued Recall (LDCR). Multivariable regression controlled for demographic factors, seizure history, loss of consciousness, posttraumatic amnesia, and acute intracranial pathology on computed tomography (CT).ResultsIn 114 mTBI patients (APOE-ε4(-)=79; APOE-ε4(+)=35), ApoE-ε4(+) was associated with long-delay verbal memory deficits (LDFR: B = -1.17 points, 95% CI [-2.33, -0.01], p = .049; LDCR: B = -1.58 [-2.63, -0.52], p = .004), and a marginal decrease on SDCR (B = -1.02 [-2.05, 0.00], p = .050). CT pathology was the strongest predictor of decreased verbal memory (IRT: B = -8.49, SDFR: B = -2.50, SDCR: B = -1.85, LDFR: B = -2.61, LDCR: B = -2.60; p