학술논문
Coronary artery plaque progression and cardiovascular risk scores in men with and without HIV-infection
Document Type
article
Author
Shaikh, Kashif; Bhondoekhan, Fiona; Haberlen, Sabina; Nakanishi, Rine; Roy, Sion K; Alla, Venkata M; Brown, Todd T; Lee, Juhwan; Osawa, Kazuhiro; Almeida, Shone; Rahmani, Sina; Nezarat, Negin; Sheidaee, Nasim; Kim, Michael; Jayawardena, Eranthi; Kim, Nicolas; Hathiramani, Nicolai; Palella, Frank J; Witt, Mallory; Ahmad, Khadije; Kingsley, Lawrence; Post, Wendy S; Budoff, Matthew J
Source
AIDS. 36(2)
Subject
Language
Abstract
ObjectiveThe aim of this study was to assess the association of cardiovascular disease (CVD) risk scores and coronary artery plaque (CAP) progression in HIV-infected participants.MethodsWe studied men with and without HIV-infection enrolled in the Multicenter AIDS Cohort Study (MACS) CVD study. CAP at baseline and follow-up was assessed with cardiac computed tomography angiography (CCTA). We examined the association between baseline risk scores including pooled cohort equation (PCE), Framingham risk score (FRS), and Data collect of Adverse effects of anti-HIV drugs equation (D:A:D) and CAP progression.ResultsWe studied 495 men (211 HIV-uninfected, 284 HIV-infected). The adjusted odds ratio (aOR) of total plaque volume (TPV) and noncalcified plaque volume (NCPV) progression in the highest relative to lowest tertile was 9.4 [95% confidence interval (95% CI) 2.4-12.1, P