학술논문
Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study
Document Type
article
Author
Zheng, Yinan; Habes, Mohamad; Gonzales, Mitzi; Pomponio, Raymond; Nasrallah, Ilya; Khan, Sadiya; Vaughan, Douglas E; Davatzikos, Christos; Seshadri, Sudha; Launer, Lenore; Sorond, Farzaneh; Sedaghat, Sanaz; Wainwright, Derek; Baccarelli, Andrea; Sidney, Stephen; Bryan, Nick; Greenland, Philip; Lloyd-Jones, Donald; Yaffe, Kristine; Hou, Lifang
Source
Aging. 14(4)
Subject
Language
Abstract
The proportion of aging populations affected by dementia is increasing. There is an urgent need to identify biological aging markers in mid-life before symptoms of age-related dementia present for early intervention to delay the cognitive decline and the onset of dementia. In this cohort study involving 1,676 healthy participants (mean age 40) with up to 15 years of follow up, we evaluated the associations between cognitive function and two classes of novel biological aging markers: blood-based epigenetic aging and neuroimaging-based brain aging. Both accelerated epigenetic aging and brain aging were prospectively associated with worse cognitive outcomes. Specifically, every year faster epigenetic or brain aging was on average associated with 0.19-0.28 higher (worse) Stroop score, 0.04-0.05 lower (worse) RAVLT score, and 0.23-0.45 lower (worse) DSST (all false-discovery-rate-adjusted p