학술논문

Association of Urine Biomarkers of Kidney Tubule Injury and Dysfunction With Frailty Index and Cognitive Function in Persons With CKD in SPRINT
Document Type
article
Source
American Journal of Kidney Diseases. 78(4)
Subject
Clinical Research
Clinical Trials and Supportive Activities
Kidney Disease
Prevention
Renal and urogenital
Good Health and Well Being
Aged
Aged
80 and over
Biomarkers
Blood Pressure
Chemokine CCL2
Cognition
Cross-Sectional Studies
Female
Frailty
Glomerular Filtration Rate
Hepatitis A Virus Cellular Receptor 1
Humans
Kidney Tubules
Male
Middle Aged
Renal Insufficiency
Chronic
cognitive function
cognitive impairment
fitness
frailty
functional status
kidney function
kidney injury
memory
renal fibrosis
tubular dysfunction
tubule injury
tubule reabsorptive capacity
urine biomarkers
vascular aging
Clinical Sciences
Public Health and Health Services
Urology & Nephrology
Language
Abstract
Rationale & objectiveThe associations of the glomerular markers of kidney disease, estimated glomerular filtration rate (eGFR) and albuminuria, with frailty and cognition are well established. However, the relationship of kidney tubule injury and dysfunction with frailty and cognition is unknown.Study designObservational cross-sectional study.Setting & participants2,253 participants with eGFR