학술논문
Acute ischaemic stroke associated with SARS-CoV-2 infection in North America
Document Type
article
Author
Dmytriw, Adam A; Dibas, Mahmoud; Phan, Kevin; Efendizade, Aslan; Johanna, Ospel; Schirmer, Clemens; Settecase, Fabio; Heran, Manraj KS; Kühn, Anna Luisa; Puri, Ajit S; Menon, Bijoy K; Sivakumar, Sanjeev; Mowla, Askan; Vela-Duarte, Daniel; Linfante, Italo; Dabus, Guilherme C; Regenhardt, Robert W; D'Amato, Salvatore; Rosenthal, Joseph A; Zha, Alicia; Talukder, Nafee; Sheth, Sunil A; Hassan, Ameer E; Cooke, Daniel L; Leung, Lester Y; Malek, Adel M; Voetsch, Barbara; Sehgal, Siddharth; Wakhloo, Ajay K; Goyal, Mayank; Wu, Hannah; Cohen, Jake; Ghozy, Sherief; Turkel-Parella, David; Farooq, Zerwa; Vranic, Justin; Rabinov, James D; Stapleton, Christopher J; Minhas, Ramandeep; Velayudhan, Vinodkumar; Chaudhry, Zeshan Ahmed; Xavier, Andrew; Bullrich, Maria Bres; Pandey, Sachin; Sposato, Luciano A; Johnson, Stephen A; Gupta, Gaurav; Khandelwal, Priyank; Ali, Latisha; Liebeskind, David S; Farooqui, Mudassir; Ortega-Gutierrez, Santiago; Nahab, Fadi; Jillella, Dinesh V; Chen, Karen; Aziz-Sultan, Mohammad Ali; Abdalkader, Mohamad; Kaliaev, Artem; Nguyen, Thanh N; Haussen, Diogo C; Nogueira, Raul G; Haq, Israr Ul; Zaidat, Osama O; Sanborn, Emma; Leslie-Mazwi, Thabele M; Patel, Aman B; Siegler, James E; Tiwari, Ambooj
Source
Journal of Neurology Neurosurgery & Psychiatry. 93(4)
Subject
Language
Abstract
BackgroundTo analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.MethodsMulticentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) and mortality at discharge, ordinal mRS (shift analysis), symptomatic intracranial haemorrhage (sICH) and occurrence of in-hospital complications.ResultsA total of 216 COVID-19 patients with AIS were included. 68.1% (147/216) were older than 60 years, while 31.9% (69/216) were younger. Median [IQR] National Institutes of Health Stroke Scale (NIHSS) at presentation was 12.5 (15.8), and 44.2% (87/197) presented with large vessel occlusion (LVO). Approximately 51.3% (98/191) of the patients had poor outcomes with an observed mortality rate of 39.1% (81/207). Age >60 years (aOR: 5.11, 95% CI 2.08 to 12.56, p