학술논문
The contribution of behavioral features to caregiver burden in FTLD spectrum disorders
Document Type
article
Author
Silverman, Hannah E; Ake, Jeannie M; Manoochehri, Masood; Appleby, Brian S; Brushaber, Danielle; Devick, Katrina L; Dickerson, Bradford C; Fields, Julie A; Forsberg, Leah K; Ghoshal, Nupur; Graff‐Radford, Neill R; Grossman, Murray; Heuer, Hilary W; Kornak, John; Lapid, Maria I; Litvan, Irene; Mackenzie, Ian R; Mendez, Mario F; Onyike, Chiadi U; Pascual, Belen; Tartaglia, Maria Carmela; Boeve, Bradley F; Boxer, Adam L; Rosen, Howard J; Cosentino, Stephanie; Huey, Edward D; Barker, Megan S; Goldman, Jill S; consortium, the ALLFTD
Source
Alzheimer's & Dementia. 18(9)
Subject
Language
Abstract
IntroductionCaregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.MethodsIn a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.ResultsApathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia.DiscussionCaregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.